Spiromesifen | C23H30O4 - PubChem

Spiromesifen is a butenolide that is but-2-en-4-olide bearing a 2,4,6-trimethylphenyl group at position 3, a 3,3-dimethylbutyryloxy group at position 4 and a spiro-fused cyclopentyl ring at position 5. It has a role as an insecticide. It derives from a 1,3,5-trimethylbenzene and a 3,3-dimethylbutyric acid.

Spinosad - Wikipedia

Spiromesifen was not irritating to the skin or the eyes of rabbits. Spiromesifen was a skin sensitizer in a Magnusson and Kligman test in guinea-pigs. In repeated-dose oral toxicity studies with spiromesifen in mice, rats and dogs, the most sensitive effect was reduction of plasma cholesterol. This is probably secondary to the inhibition of

Insecticide Poisoning in Dogs | petMD

structurally similar to spiromesifen, which is also a tetronic acid insecticide. Available product chemistry, residue, toxicology, ecological effects and environmental ... in dogs, rats and mice, manifested as Leydig cell vacuolation in dogs, hypertrophy in ... Evidence of developmental toxicity was not observed in the rat and rabbit developmental

5.22 SPIROMESIFEN (294) TOXICOLOGY - fao.org

In short- and long-term studies of oral toxicity in mice, rats and dogs, the primary target organs of toxicity of spirodiclofen were the adrenal glands and testes. The predominant finding was vacuolation of the adrenal cortex, which was noted in the mouse, rat and dog, and was often accompanied by …

United States Office of Prevention, Pesticides ...

Spinosad is low in toxicity to people and other mammals. However, if it gets on your skin or in your eyes it can cause irritation and redness. In one study, 28 dogs were fed low to moderate doses of spinosad.

5.21 SPIRODICLOFEN (237) TOXICOLOGY

also present in dogs. Spiromesifen did not show any genotoxic and carcinogenic potential. The relevant repeat dose NOAEL is 3 mg/kg bw/day. Spiromesifen was tested in reproductive and developmental toxicity studies showing effects only as a consequence of maternal toxicity (reduced

Federal Register :: Spiromesifen; Pesticide Tolerances

Spinetoram has low acute toxicity via the oral, dermal and inhalation routes of exposure (acute Toxicity Category IV). It is a dermal sensitizer but not an eye or dermal irritant. In subchronic toxicity studies conducted in mice, rats, and dogs, spinetoram produced no adverse

Spinosad General Fact Sheet

Just because abamectin has a lower toxicity rate toward mammals doesn't mean that your cat won't be affected by a run-in with this chemical. However, that doesn't mean you're out of the woods just yet. Make sure that you're storing your pest control products properly so that your cat doesn't stick its nose where it …

Conclusion regarding the peer review of the pesticide risk ...

Acute toxicity studies for spiromesifen support an overall toxicity Category III. 2. ... There was no indication in the rat or mouse for an oncogenic effect of spiromesifen. A 1-year feeding study with dogs demonstrated a NOAEL of 11.5 and 10.8 mg/kg bw day for males and females, respectively based on decreased body weights, liver effects ...

Pesticide Fact Sheet - US EPA

maternal toxicity. DEVELOPMENTAL TOXICITY: Spiromesifen is not a primary developmental toxicant based on developmental toxicity studies in rats and rabbits. Developmental effects observed in rats at high doses were secondary to maternal toxicity. Neurotoxicity Spiromesifen was not neurotoxic in acute (oral gavage) and subchronic (diet)

Abamectin Facts (Definitive Safety Guide) - Pest Strategies

In toxicity studies in dogs, indoxacarb induced Heinz bodies and hemolytic anemia when administered orally at 18-19 mg/kg/day. 26 This effect is suspected to be due to a metabolite of indoxacarb, N-hydroxylarylamine, which causes oxidative damage to red blood cells. 27 Based on in vitro studies, the relative sensitivity of species to the ...

Spiromesifen; Notice of Filing a Pesticide Petition to ...

There was no evidence of neurotoxicity in the acute or subchronic neurotoxicity or any other studies. 3. Conclusion. For spiromesifen, EPA determined that the 10X safety factor to protect infants and children should be removed. A 1X safety factor is appropriate because: There is a complete toxicity data base for spiromesifen.

Bayer Environmental Science - domyown.com

Chronic Toxicity Spiromesifen caused effects in the liver, uterus, adrenal and/or thyroid (secondary effect) in chronic studies in rats and dogs. Assessment Carcinogenicity Spiromesifen was not carcinogenic in lifetime feeding studies in rats and mice. ACGIH None. NTP None. IARC None. OSHA None. Reproductive & Developmental Toxicity

Indoxacarb - an overview | ScienceDirect Topics

secondary to stark maternal toxicity. DEVELOPMENTAL TOXICITY: Spiromesifen is not a primary developmental toxicant based on developmen-tal toxicity studies in rats and rabbits. Developmental effects observed in rats at high doses were secondary to maternal toxicity. Neurotoxicity Spiromesifen was not neurotoxic in acute (oral gavage)

Spiromesifen; Pesticide Tolerance, 21631-21641 [05-8120 ...

Dogs given dicrotophos in their diets at 0, 0.16, 1.6, and 16 ppm for 2 years showed some instances of slight excessive salivation and at the 100 ppm concentration fairly consistent excessive salivation, soft stools and/or tremors.

Bayer CropScience - Amazon Simple Storage Service

hazards of and to make a determination on aggregate exposure for spiromesifen including exposure resulting from the tolerances established by this action. EPA's assessment of exposures and risks associated with spiromesifen follows. A. Toxicological Profile EPA has evaluated the available toxicity data and considered its validity,